Mill Valley, California

California Institute for Resilience & Flourishing

We translate the science of resilience and flourishing into interventions, policy, and practice that actually reach the people who need them.

A crisis in relational health and emotional resilience

Growing distrust, mental health challenges in youth and older adults, declining birth rates, and shortened life expectancy trace back to the same root: chronic stress driven by social isolation, devaluation, and disconnection.

Chronic stress breaks down the social fabric a functioning democracy depends on, lowers immune function, and drives cognitive, mental, and physical illness — it is implicated in 9 out of 10 deaths nationwide. Healthcare and public policy largely treat the symptoms of this crisis, not the causes.

Any disease can kill us. What determines whether it does is the underlying resilience of the body it's attacking.

We keep funding the ambulance at the bottom of the cliff. It's time to fund the guardrail at the top — and that's what the Institute exists to do.

$282B Annual Cost of Mental Illness to the U.S. Economy Columbia Business School, Abramson et al.
$1T Lost to Depression & Anxiety Worldwide Each Year World Health Organization
$300B Annual Cost of Workplace Stress in the U.S. American Institute of Stress

California Institute for Resilience & Flourishing aerial view Residential housing at California Institute for Resilience & Flourishing Senior living community Open spaces at California Institute for Resilience & Flourishing Fitness center and amenities

The Institute is based on a 130-acre campus in the Strawberry neighborhood of Mill Valley, California — land that has held educational and community purpose since 1953, with sweeping views of Richardson Bay and San Francisco, and was once considered as a site for the United Nations. Today it houses our research laboratory, training programs, and the day-to-day work of translating resilience science into practice.


Closing the gap between knowing and doing

California Institute for Resilience & Flourishing exists because the science of resilience is decades ahead of its adoption. We treat closing that gap as core scientific work, not an afterthought.

Most health and social innovations fail not because they don't work, but because adoption is unsolved. Payers, providers, policymakers, and communities aren't at the table when interventions are designed. We bring those stakeholders in from day one.

We define, test, and share metrics for resilience at every level — individual, relational, community, and ecosystem — integrating biomarkers and behavioral signals with community-informed qualitative measures.


A praxis-first model

Research universities rarely reward turning science into real-world impact. We put that translation front and center — training scholar-practitioners who pair rigorous research with community organizing, storytelling, science communication, and policy co-creation, so our researchers, educators, clinicians, and leaders never have to choose between scientific rigor and social impact.


A Nested Approach to Resilience and Flourishing

Resilience isn't the absence of stress. It's the capacity to endure it, move through it, and come out the other side intact.

Each level of our work is nested within the next — moving from micro to macro, from what we can measure and test today to the conditions that make resilience possible at scale.


Five ways we put research into practice

Each program moves the same evidence base a step closer to the people who need it — from the lab bench to the classroom, the clinic, and the community.

Research Lab

The nation's first collaboratory dedicated to the science and practice of social safety, relational health, and resilience — studying how social context and stress shape human development and disease risk to build scalable strategies for reducing risk and strengthening resilience.

Professional Education

Training health care providers, educators, and organizational leaders through micro-credential pathways that bring social-health practices directly into clinics, schools, and community systems.

Relational Health Professionals Program

Training and placing Relational Health Professionals in schools, workplaces, and communities through a scalable workforce model — building skills in listening, community-building, and counseling that sustain resilient communities of care through life's major transitions.

Life Worth Living Project

A nationwide listening and storytelling initiative exploring what makes life meaningful, purposeful, and joyful — insights that inform our policy work and creative ventures, and envision pathways toward stronger communities.

Campus Apprenticeship

A paid "live, work, earn, learn" workforce development program building local economic stability, personal and professional skills, and a lasting sense of community, purpose, and belonging.

Help us close the gap faster

We're raising our first $5M philanthropic round to match the grant funding already underway. Meet the team, tour the campus, or support the work directly.

Working at the intersection of stress science, precision medicine, and public health — asking how adversity gets under the skin, and what it actually takes to build resilience across a human life.

Founded and directed by George Slavich, PhD, the laboratory brings together postdoctoral researchers and collaborators across six active areas of funded inquiry, with ongoing research collaborations spanning 200+ universities worldwide, including Stanford, Harvard, Yale, UCSF, and UCLA. Across all six, the lab integrates biomarkers and behavioral signals with community-informed qualitative measures — and treats equity as a design principle, not an afterthought.

Grant 1 · ARPA-H / Buck Institute

Stress, Resilience, and Healthy Aging: The THRIVE Initiative

In partnership with the Buck Institute for Research on Aging and the YMCA, and funded by ARPA-H, the laboratory is a core partner in THRIVE: Transforming Health — Reclaiming Intrinsic Vitality for Everyone. THRIVE is developing the first FDA-grade Intrinsic Capacity Score — a validated, scalable measure to predict healthy aging at the population level, moving beyond the absence of disease toward a positive science of vitality and healthspan. The $3.7M award anchors the lab's core operating budget for four years.

Grant 2 · California Governor's Office / NASEM

Women's Mental Health

Funded by the California Governor's Office of Planning and Research, the laboratory advances the science and practice of women's mental health. Women are twice as likely as men to experience depression and anxiety across the lifespan — a disparity shaped by hormonal transitions, social determinants, and decades of underinvestment in women's health research. The laboratory contributes to a national effort to change this, including through policy recommendations developed with the National Academies of Sciences, Engineering, and Medicine.

Grant 3 · NIH SBIR

Alzheimer's Prevention in Women: The Flourish All Initiative

In partnership with the digital health platform Flourish All and funded by NIH, the laboratory is investigating stress reduction as a pathway to Alzheimer's prevention in midlife women. Women account for two-thirds of all Alzheimer's patients — a disparity driven in part by the neuroinflammatory effects of menopause and the disproportionate stress burden women carry across their lives.

Through an NIH-funded clinical trial, the laboratory is testing an AI-powered precision intervention personalized to each participant's stress levels, sleep, and physical activity, tracking its effects on inflammation, cognitive performance, and Alzheimer's risk biomarkers — with the goal of producing a replicable model for protecting cognitive health in the populations most at risk.

Grant 4 · CIAPM

CalStar: Reducing the Health Impact of Early-Life Stress

CalStar, the lab's foundational study, quantified how adverse childhood experiences shape adult stress and health, and tested a fully remote, precision-medicine-style lifestyle intervention to reduce chronic stress. The trial is complete and the intervention proved effective — the evidence base and remote-trial methods it produced now anchor the lab's broader intervention toolkit.

Grant 5 · Philanthropic Partnership

EmRes: Reducing Burnout and Anxiety in Healthcare Workers

Funded by a private philanthropic gift, this trial tested the EmRes emotion-regulation protocol's effectiveness at reducing anxiety among healthcare workers, outperforming an active comparison treatment. EmRes is now expanding into community workshops for family caregivers, including a partnership with the Caring for Caregivers program in Irvine, California.

Grant 6 · CIAPM

BALANCE: Emotional Regulation for LGBTQ+ Youth

BALANCE investigates an app-based intervention to reduce depression and strengthen emotional regulation among youth, with particular attention to LGBTQ+ youth. The study draws on community-based research methods, including a youth advisory board, to reach and support populations too often left out of clinical research.


The People Behind the Science

George Slavich, PhD
Chief Science Officer, Co-Founder & Laboratory Director

George Slavich is one of the world's leading researchers on stress, resilience, and human health. He is a Professor at UC Irvine Medical School and the originator of Social Safety Theory — a landmark framework describing how experiences of social safety and threat shape the brain, immune system, and behavior across the lifespan. His work sits at the intersection of clinical psychology, neuroscience, and immunology, asking a deceptively simple question: why does social experience get under the skin, and what can we do about it?

Slavich directs the California Stress, Trauma, and Resilience (CAL STAR) Network and previously founded and directed the UCLA Laboratory for Stress Assessment and Research. His research has produced hundreds of peer-reviewed papers in journals including JAMA Psychiatry and Nature Medicine, and has earned him recognition as a Beck Institute Scholar and Branco Weiss Fellow. He trained at Stanford University, completed his PhD in clinical psychology at the University of Oregon, and conducted his clinical internship at McLean Hospital/Harvard Medical School.

Summer Mengelkoch, MS, PhD
Post-Doctoral Research Fellow (she/her)

Summer Mengelkoch is an experimental social psychologist who uses evolutionary theory to study the relationships between biology and behavior — including how inflammation shapes decision-making, how hormonal contraceptives affect women's stress responses, and how early-life stress echoes into adult health. She completed her BA at the University of Minnesota, her MS at Texas Christian University under Dr. Sarah E. Hill, and her PhD at TCU in 2022. She is also a co-founder and operations director of EOS BioAnalytics, a nonprofit working to make bioanalytic methods more accessible across scientific disciplines.

Jeff Gassen, PhD
Post-Doctoral Research Fellow (he/him)

Jeff Gassen is a postdoctoral scholar at UCLA's Semel Institute for Neuroscience and Human Behavior and Senior Statistician for the UCLA-UCSF ACEs Aware Family Resilience Network. His research uses multivariate and multilevel statistical methods to study how environments, biology, and health interact — with particular attention to the long reach of early-life stress. He received his PhD in Experimental Psychology from Texas Christian University in 2020 and completed a postdoctoral fellowship in Biological Anthropology at Baylor University before joining UCLA.

Jenna Alley, PhD
Post-Doctoral Research Fellow (she/her)

Jenna Alley leads the CAL STAR Network's Social Justice, Equity & Inclusion workgroup. Her research examines the psychobiological pathways through which stress, adversity, and abuse affect the mental, physical, and sexual health of sexually and gender diverse populations. She holds a PhD in Developmental Psychology from the University of Utah. Throughout her work, Jenna attends closely to how race, ethnicity, gender identity, sexual orientation, socioeconomic status, and other intersecting factors shape human experience — and actively works to change the structural conditions that marginalize those perspectives in research and academic life.

Kimya Afshar
Laboratory Manager

Kimya Afshar manages day-to-day operations of the California Institute for Resilience & Flourishing research laboratory, bringing experience across neuroscience, clinical research, and cognitive science. She spent nearly three years as a research assistant and then laboratory manager at UCLA's Semel Institute for Neuroscience and Human Behavior, and has contributed to research in transcranial functional ultrasound stimulation and clinical settings at iSono Health. She holds a BA in Cognitive Science with a computing specialization from UCLA.

California Institute for Resilience & Flourishing is led by a team of practitioners, researchers, and institution-builders who share a conviction that the gap between knowing and doing is the defining challenge of our moment.

George Slavich, PhD
Founder & Research Director

George Slavich is a Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and founding director of the UCLA Laboratory for Stress Assessment and Research. His research focuses on the psychological and biological mechanisms linking stress and health, and he is the originator of Social Safety Theory — a framework describing how experiences of social safety and threat shape the brain, immune system, and human behavior across the lifespan. He directs the California Stress, Trauma, and Resilience (CAL STAR) Network and has authored hundreds of papers in journals including JAMA Psychiatry and Nature Medicine. He trained at Stanford, the University of Oregon, and McLean Hospital/Harvard Medical School.

Zak Williams, MBA
Board Chair & Co-Founder

Zak Williams is CEO and co-founder of PYM, a neurotransmitter health company, and a leading voice in the mental health advocacy space. Following the death of his father, Robin Williams, Zak channeled personal grief into public purpose — speaking openly about his own journey through anxiety and depression and working to dismantle the stigma around mental health. He has served as Chairman of Bring Change to Mind, as a US trustee for United for Global Mental Health, and as an advisor to organizations including Project Healthy Minds and Inseparable. He holds an MBA from Columbia Business School and a BA in Linguistics from NYU.

Lily Lamboy, PhD
Executive Director

Lily Lamboy is a social impact executive, educator, and scholar whose work centers on how social and economic resources can be organized to ensure care for all people across their lifespans. She is co-founder and managing director of the Modern Family Institute and previously led Diversity, Equity & Inclusion at Stripe and Blue Shield of California. She holds a PhD in Political Science from Stanford University, where she also taught in the Rhetoric and Feminist, Gender, and Sexuality Studies programs, and has published peer-reviewed work with Cambridge University Press and the International Panel on Social Progress.

Kimberly Myers-Hewlett, PhD, MBA
Board Member

Kimberly Myers-Hewlett is President of the Myers Family Foundation and a family council member of the Flora Family Foundation, with a career spanning philanthropy, higher education, and community finance. She previously served as Senior Vice President of Donor Engagement at the Silicon Valley Community Foundation and held senior roles at Rockefeller Philanthropy Advisors and Stanford University Medical School. She serves on the boards of the National Center for Family Philanthropy and Seacology, and on the board of visitors for Indiana University's Lilly Family School of Philanthropy. She holds a BA from Stanford and an MBA from Indiana University's Kelley School of Business.

Aneel S. Chima, PhD
Board Member

Aneel Chima is Director of the Division of Health and Human Performance at Stanford University and founding director of the Stanford Flourishing Project, where his work asks how individual and collective flourishing can be scaled in an era of exponential technological change. He co-founded the Wellbeing, Innovation, and Social Change in Education (WISE) Network — a global movement spanning 100 universities — and co-convenes the Flourishing Academic Network across leading North American research institutions. Before academia, he spent over a decade as co-founder of AT THE CORE, a consultancy focused on the neurophysiological and emotional drivers of leadership performance. He is also a longtime Buddhist contemplative practitioner.


Jennifer Siebel Newsom
Advisor

Jennifer Siebel Newsom is an award-winning filmmaker and California's First Partner. As an advisor to the Institute, she brings a public storytelling lens to translating the science of resilience into cultural change.

Josh Fryday
Advisor

Josh Fryday is California's Chief Service Officer and a civic engagement leader. As an advisor to the Institute, he brings experience mobilizing public service infrastructure at scale to the Institute's work translating research into policy and practice.

We're launching our first philanthropic campaign — $5M to match the grant funding we've already secured, bringing total resources to $10M.

Two live federal grants — PROSPR (ARPA-H) and Flourish All (NIH/NIA) — are already funding our research. This raise builds the infrastructure around that science: a dedicated wet lab, key hires, and the launch of our professional education programs, so the evidence we generate reaches the people who need it faster.

$5M New Philanthropic Goal
$10M Total Campaign Resources
$4 Returned for Every $1 Invested in Treatment World Health Organization

Healthy aging, workforce productivity, chronic disease, and mental health are different budget lines with the same root cause. Fund the root, and every line moves.

We're not a wellness brand selling vibes. We're a research institute working with 200+ universities, translating hard science into interventions people can actually use.


Three priorities for Year One

Wet Lab — $1.5M

A first-of-its-kind facility for analyzing the biomarkers of chronic stress — the mechanistic thread connecting our healthy-aging and Alzheimer's-prevention research.

Hiring

Expanding our research and practice teams with leading experts to grow the lab's capacity and reach.

Educational Programming

Launching our ready-to-go training and MOOC on chronic stress and resilience for medical, psychological, and community professionals.

Schedule a Tour or Ask a Question

Interested donors are welcome to inquire directly and schedule a visit to our 130-acre campus in Mill Valley. Reach out to Executive Director Lily Lamboy to start the conversation.